Sophie, Huaqian Wang (王华倩)

Scientific Research Project

lPI, Study on individualized self-assembled anticancer vaccine based on the structure of cholera toxin AB5(Project number:81501429), National Natural Science Foundation of China,2016/01-2018/12;

lPI, Anti prostate cancer activity and mechanism of Acanthus ilicifolius (Project number:2015A030302075), Special fund for public welfare research and capacity building in Guangdong Province, 2015/08-2017/12;

lPI, Construction and expression of viral brain targeting delivery vector (Project number:S2012040007488), Natural Science Foundation of Guangdong Province;

lPI, Molecular modification of a bifunctional protein against Parkinson's disease and type 1 diabetes mellitus (Project number:12ZK0068), Cultivation project of outstanding young innovative talents in Colleges and universities of Guangdong Province;

lPI, Preparation and mechanism of therapeutic peptide vaccine for type I diabetes mellitus (Project number:103034), Doctoral initiation project of Guangdong University of Technology;

Publications：

[1]An in vitro and in vivo study of the brain-targeting effects of an epidermal growth factor-functionalized cholera toxin-like chimeric protein. Huafeng He, Danmin Lin, Jiajie Sun, Xianying He, Tiantian Wang, Yinglin Fang, Kaixiang Fan, Xinxin Chen, Suqing Zhao, Xi Zheng, Kun Zhang,Huaqian Wang*. Journal of Controlled Release(IF=7.8), 2020, 322(10):509-518.

[2]Purification and characterization of a novel cell-penetrating carrier similar to cholera toxin chimeric protein. Weiping Lin, Xi Zheng,Huaqian Wang*,Lin Yu,Xiaofen Zhou，Yunxiao Sun, Zhiyun Du，Kun Zhang. Protein Expression and Purification(IF=1.513). 2017,129:128-134.

[3]Inhibition of IL-6 expression in LNCaP prostate cancer cells by a combination of atorvastatin and celecoxib.Wang H, Cui XX, Goodin S, Ding N, Van Doren J, Du Z, Huang MT, Liu Y, Cheng X, Dipaola RS, Conney AH, Zheng X.Oncol Rep(IF=3.4178). 2014,31(2):835-41.

[4]Schiff base derived Fe3+-selective fluorescence turn-off chemsensors based on triphenylamine and indole: synthesis, properties and application in living cells, Chengqiang Pan, Kai Wang, Shaomin Ji,Huaqian Wang*, Zongzhi Li,Huahong He,Yanping Huo, RSC Adv.(IF=3.119), 2017, 7:36007.

[5]Anticancer activities of Acanthopanax trifoliatus (L) Merr extracts are associated with inhibition of NF-kB activity and decreased Erk1/2 and Akt phosphorylation.Huaqian Wang, Dongli Li, Yujing Lu, Xiaoxing Cui, Xiaofen Zhou, Weiping Lin, Allan HConney, Kun Zhang, Zhiyun Du, Xi Zheng. Asian Pacific journal of cancer prevention. 2014,15(21): 9341-46.

[6]Antioxidant and Anti-inflammatory Properties of Chinese Ilicifolius Vegetable (Acanthopanax trifoliatus (L) Merr) and Its Reference Compounds.Huaqian Wang, Dongli Li, Zhiyun Du, Mou-Tuan Huang, Xiaoxing Cui, Yujing Lu, Chenyue Li, Swee Lian Woo, Allan H Conney, Xi Zheng, and Kun Zhang. Food Sci. Biotechnol (IF=1.513). 2015,24(3): 1131-1138.

[7]Immunotherapy of autoimmune diabetes by nasal administration of tandem glutamic acid decarboxylase 65 peptides.Wang H, Yang J, Jin L, Feng J, Lu Y, Sun Y, Li T, Cao R, Wu J, Fan H, Liu J. Immunol Invest(IF=2.511). 2009, 38(8):6 :690-703

[8]Effects of pyridine analogs of curcumin on growth, apoptosis and NF-κB activity in prostate cancer PC-3 cells. Wei X, Zhou D,Wang H, Ding N, Cui XX, Wang H, Verano M, Zhang K, Conney AH, Zheng X, DU ZY.Anticancer Res(IF=1.994). 2013,33(4):1343-50.

[9]Vaccination with the repeatβ-hCG C-terminal peptide carried by heat shock protein-65 (HSP65) for inducing antitumor effects. Yang J, Zhang Y,Wang H, Gao Z, Wang Z, Liu B, Zhang X, Du M, Huang X, Xu M, Wu J, Li T, Liu J, Cao R. Tumour Biol.2012, 33(5):1777-1784.

[10]Administration of heat shock protein 65 inhibits murine melanoma growth in vivo.Yang J, Xie Y,Wang H, Yao Y, Hou J, Ma Y, Zhang Q, Xing Y, Wu J, Li T, Zheng J, Liu J, Cao R. Mol Med Report(IF=2.1). 2013,7(1):1791-2997.

[11]Vaccination with a potent DNA vaccine targeting B-cell epitopes of hGRP induces prophylactic and therapeutic antitumor activity in vivo. Yong L, Huiyong Z, Jing H,Huaqian W, Xiangbing H, Yanjun M, Xiaoyu G, Li H, Yanan Y, Rongyue C, Hao F, Jingjing L,Jie W. Gene Therapy (IF=4.128). 2010, 17(4):459-68.

[12]A novel human parathyroid hormone (1-34) analog for the treatment of osteoporosis. Feng J, Liu Y, Xing Y,Wang H, Li T, Liu J, Fan H, Cao R. Peptides(IF=2.843). 2009, 30(6):1173-80.

[13]Study on preparation and unique properties of a novel insulin analogue with N-terminal Arg-4, Pro-3, Lys-2, Pro-1extension at insulin B-chain. Yong L, Huiyong Z, Jing F,Huaqian W, Kejun Y, Yanan Y, Suli L, Xuejun W, Yuhan M, Rongyue C, Hao F, Taiming L, Jingjing L. Regul Pept. 2009, 157(1-3):92-8.

[14]Specific antibodies elicited by a novel DNA vaccine targeting gastrin-releasing peptide inhibit murine melanoma growth in vivo. Fang J, Lu Y, Ouyang K, Wu G, Zhang H, Liu Y, Chen Y, Lin M,Wang H, Jin L, Cao R, Roque RS, Zong L, Liu J, Li T. Clin Vaccine Immunol. 2009, 16(7):1033-9.

[15] Synthesis and biological evaluation of curcumin derivatives containing NSAIDs for their anti-inflammatory activity. Liu W, Li Y, Yue Y, Zhang K, Chen Q,Wang H, Lu Y, Huang MT, Zheng X, Du Z. Bioorg Med Chem Lett (IF=2.572). 2015, 25(15):3044-51.

[16]Combination of 12-O-tetradecanoylphorbol-13-acetate with diethyldithiocarbamate markedly inhibits pancreatic cancer cell growth in 3D culture and in immunodeficient mice. Huang H, Cao K, Malik S, Zhang Q, Li D, Chang R,Wang H, Lin W, Van Doren J, ZhangK, Du Z, Zheng X. Int J Mol Med (IF=3.098). 2015, 35(6):1617-24.

[17]Potent inhibitory effect of terpenoids from Acanthopanax trifoliatus on growth of PC-3prostate cancer cells in vitro and in vivo is associated with suppression of NF-κB and STAT3 signalling. Dongli Li, Zhiyun Du, Chenyue Li, Yue Liu, Susan Goodin, Huarong Huang, Yan He, Yuan Zhang,Huaqian Wang, Xi Zheng*, Kun Zhang. Journal of Functional Foods (IF=3.701). 2015, (15): 274–283.

Patents：

[1]Huaqian Wang,Danmin Lin,Huafeng He,Caiyan Song,Jiajie Sun,Wei Long,Zhiyun Du,Suqing Zhao,Kun Zhang. Anti-tumor chimeric protein, anti-tumor vaccine and anti-tumor vaccine administered by nasal mucosa,201811119727.6.

[2]Huaqian Wang,Huafeng He,Danmin Lin, Weiping Lin, Tiantian Wang,Chunxing Pan,Zhiyun Du,Suqing Zhao,Kun Zhang. A method of gene expression enhancement and its preparation,CN106318962 A .

[3]Huaqian Wang,Xiaofen Zhou, Weiping Lin. A brain targeting multi subunit protein and its preparation method and Application,CN 104387472 A.

[4]Xi Zheng, Weiping Lin,Huaqian Wang,Zhiyun Du,Kun Zhang. Construction and application of drug delivery vector based on CT structure of cholera toxin,CN105504065A.

[5]Jingjing Liu,Huaqian Wang,Yunxiao Sun. A novel therapeutic polypeptide nasal vaccine for type 1 diabetes mellitus and its preparation method,101574517B.

[6]Kun Zhang,Ruilian Hu,Huaqian Wang,Alan Koney, Zhiyun Du, Xi Zheng,Chenyue Li, Junxia Zheng, Yunjing Lu,Panpan Wu, Huarong Huang, Yanxiong Fang, Suqing Zhao, Jian Wang, Huaqiang Zeng. A kind of Acanthus ilicifolius extract and its preparation method and Application.CN102920759B.